Mechanoluminescent materials that convert mechanical and acoustic stimuli into optical signals provide unique opportunities for self-powered sensing and bioapplications, including excitation-light-free temperature sensing and sono-optogenetics. Here, we show multifunctional ZnS/CaZnOS heterostructures co-doped with Mn 2+ and Nd 3+ that integrate force- and sound-induced mechanoluminescence (ML) with luminescence thermometry operating in biologically relevant near-infrared (NIR) windows. The engineered materials promote efficient force- and sound-to-photon conversion, yielding intense and reproducible ML under friction and focused ultrasound excitation. Distinct excitation pathways result in markedly different emission profiles for photoluminescence (PL) and ML, with enhanced Nd 3+ NIR emission under acoustic stimulation. By exploiting the luminescence intensity-ratios technique for thermally …